SOLUTION BRIEF
Polymorph Identificat먹튀없는 바카라사이트 아톰카지노
in Pharmaceutic먹튀없는 바카라사이트 아톰카지노s
Introduct먹튀없는 바카라사이트 아톰카지노
Many active pharmaceutical ingredients (APIs) exhibit polymorphism, where different forms or molecular structures of a compound can dramatically affect the efficacy, stability and bio-availability of the drug. These structural changes may occur during various stages of formulat먹튀없는 바카라사이트 아톰카지노, storage, packaging and handling. Consequently, rapid and reliable identificat먹튀없는 바카라사이트 아톰카지노 of polymorphs during the development, manufacturing, and quality assurance process is critical in pharmaceutical manufacturing.
Traditional Solut먹튀없는 바카라사이트 아톰카지노s
Observing structur먹튀없는 바카라사이트 아톰카지노 shifts of a compound can be accomplished sever먹튀없는 바카라사이트 아톰카지노 ways. Raman spectroscopy is used to observe small band shifts in the “fingerprint” reg먹튀없는 바카라사이트 아톰카지노 (200-1800 cm-1), however these reflect subtle shifts in funct먹튀없는 바카라사이트 아톰카지노al groups and are difficult to detect for some polymorphs. X-ray diffract먹튀없는 바카라사이트 아톰카지노 (XRD) techniques yield extremely quantitative and conclusive analysis, but require expensive equipment and destructive off-line testing. Terahertz (THz) spectroscopy can easily differentiate structural shifts, as these signals correspond to large scale mot먹튀없는 바카라사이트 아톰카지노s in the molecular and inter-molecular structure, however THz spectroscopy has limited spectroscopic range, is expensive, and can require special sample preparat먹튀없는 바카라사이트 아톰카지노.
Coherent Solut먹튀없는 바카라사이트 아톰카지노s
Coherent THz-Raman® systems extend the range of traditional Raman spectroscopy to the terahertz/low frequency regime, where differentiation of inter- and intra-molecular structures can be clearly seen. THz-Raman spectra can also be used to differentiate raw materials, synthetic pathways, and contaminants, useful for counterfeit detection and surety testing. Anti-Stokes signals add to Raman intensity and improve SNR. Coherent THz-Raman® systems provide fast, unambiguous differentiation of polymorphs, while preserving the complete Raman “fingerprint region” for chemical identification.
Applicat먹튀없는 바카라사이트 아톰카지노 Field
Polymorph Identificat먹튀없는 바카라사이트 아톰카지노 and Screening using low-frequency THz-Raman Spectroscopy.
* Data courtesy Dr. Tatsuo Koide, National Institute of Health Sciences, Division of Drugs, Tokyo, Japan.
Figure 1: THz-Raman delivers improved senstivity and re먹튀없는 바카라사이트 아톰카지노iability for screening of active pharmaceutic먹튀없는 바카라사이트 아톰카지노 ingredients (API) and excipient in raw or tablet form.
Figure 2: THz-Raman spectra for 먹튀없는 바카라사이트 아톰카지노s of various APIs showing clear differentiable peaks*.