An Introduction to THz-Raman 무료 바카라 게임

THz-무료 바카라 게임 System Requirements

Every THz-무료 바카라 게임 system has four things in 무료 바카라 게임mmon:

1. A wavelength stabilized laser source
2. Narrowband (< 5 cm^-1) spec무료 바카라 게임al clean-up filters
3. Narrowband (< 5 cm^-1) Rayleigh scatter blocking filters
4. A spec무료 바카라 게임ometer that can detect the low frequency signals

The Rayleigh filter, a +/- 5 cm1 bandwidth notch filter, should be the limiting factor to how low into the 무료 바카라 게임-domain the system can detect. However, for the Rayleigh filter to function properly, it is critical that the laser’s output spectrum be extremely stable, have a very narrow linewidth, and exhibit extremely low noise from amplified spontaneous emission (ASE) or side bands within the transmission region of the notch filters. It is also essential that the center wavelengths of both the filters and the laser remain “spectrally synchronized” to one another during operation to avoid leaking of the Rayleigh signal and saturation of the spectrometer’s detector. As an integrated manufacturer of lasers, filters and optical systems, Coherent spectrometers and modules are all designed to perfectly maintain this synchronization, ensuring robust, easy to operate performance at all times.

An additional advantage of these systems is that since Raman spectra are measured as a relative shift from the laser frequency, THz-무료 바카라 게임 systems can use lasers at any wavelength in the visible or near infrared (NIR) to probe these low-energy vibrational modes, eliminating the need for a THz laser source. This enables a much simpler and less-costly spectral collection scheme, allowing for the use of glass optics and fibers, compact and inexpensive diode and diode-pumped solid-state (DPSS) laser sources, and silicon detectors and detector arrays. THz-무료 바카라 게임 systems are also capable of detecting anti-Stokes Raman shifts, less than -5 cm^-1, which provide additional information about the sample, including local effective temperature. Therefore THz-무료 바카라 게임 systems can simultaneously measure both the chemical and structural fingerprints of materials with high throughput in a single measurement.

The combined benefits of THz spectral information with the ease of use of 무료 바카라 게임 spectroscopy now make it a powerful solution for applications that are interested in both the chemical and structural properties of materials. THz-무료 바카라 게임 has been rapidly adopted by the pharmaceutical industry [4-9] and is also getting traction in polymers [10], semiconductors [11-13], and biomedical diagnostics [14].

Low-frequency Vibrat무료 바카라 게임al Modes

As described above, low-frequency peaks result from intermolecular vibrations such as phonon modes and lattice vibrations. In crystalline samples, the position (shift) of the peaks are specific to the composition (chemical and structural) details of the crystal. And the bandwidth and intensity of these sharp low-frequency peaks are directly related to the degree of structure (crystallinity) of the sample. In contrast, amorphous solids and liquids have a broad unresolved peak known as the boson peak. Therefore, the THz-무료 바카라 게임 spectrum is a useful tool to quantitatively analyze sample crystallinity and to classify different allotropes and polymorphs. Although polymorphic analysis is a more popular application, it is easier to understand by examining the THz-무료 바카라 게임 spectra of different allotropes to better illustrate the properties of low-frequency vibrational modes.

Sulfur, which has over 30 allotropes, has been extensively studied due to its importance in a wide range of chemical processes in both life sciences and industrial applications [15]. The allotrope α-sulfur has been shown to have 24 different intermolecular vibrations, many of which are 무료 바카라 게임 active in the 30 cm^-1 - 100 cm^-1 region of the spectrum [16]. In a paper presented at the 2013 SPIE Defense, Security, and Sensing conference, Heyler et al. demonstrated how these vibrational modes could be detected using THz-무료 바카라 게임 [3]. They went on to show that as the sample of α-sulfur was heated above 95.6°C, it underwent a form change to the allotrope β-sulfur and then liquified at 115.2°C. The transition from the α form (orthorhombic) to the less ordered β form (monoclinic) could easily be detected as the increased disorder leads to a “blurring” of the modes in the 무료 바카라 게임 spectrum below 100 cm^-1 as it approaches more of a boson peak structure [Figure 2]. After melting and forming the y form (liquid), the structural modes in the THz-무료 바카라 게임 domain completely meld together showing only the purely boson band typical of an ordinary liquid [17]. In contrast, the modes in the chemical fingerprint region were not significantly affected by the form change as evident when comparing the peak locations of the spectra above 100 cm^-1. All the spec무료 바카라 게임a in figure 2, were collected using the Coherent TR-MICRO THz-Raman module attached to an upright microscope and a fiber-coupled spec무료 바카라 게임ometer. A schematic representation of the set-up is shown in figure 3.

The THz-무료 바카라 게임 unit contains a single frequency excitation laser, precisely matched to ultra-narrow-band (volume holographic) laser line and notch filters. The notch filters are specifically designed to ensure maximum throughput of the 무료 바카라 게임 scatter while also attenuating the Rayleigh scatter with an optical density (OD) greater than 9, enabling their use with inhomogeneous samples. Finally, the remaining 무료 바카라 게임 scatter is coupled to a spectrometer through a fiber optic cable. A more detailed explanation of the optical design is available in the conference proceedings [3].

Applicat무료 바카라 게임s in Pharmaceuticals

Polymorphism is a critical and common characteristic of active pharmaceutical ingredients (APIs). It has a direct impact on drug substance bioavailability, manufacturability, and quality/performance [18]. Since polymorphic compounds have the same base molecular composition but different bulk structural orientations, THz-Raman is far better suited than conventional infrared (IR) and Raman spectroscopies to determine the polymorphic form. For the sake of completeness, it should be noted that in some cases, polymorphic differences can lead to subtle peak shifts in the chemical fingerprint region of the Raman spectra [19,20] due to damping of intramolecular vibrations. That said, the spectral changes in the low-frequency range tend to be far more pronounced (up to 10x stronger) and more easily differentiable without the need for complex chemometric analysis. Additionally, as Larkin et al. demonstrated in a 2014 article published in Applied 무료 바카라 게임, “Low-frequency Raman spectra of large aromatic species typical of APIs provide remarkably intense bands below 200 cm^-1 with complex spectral features [9].” They went on to explain that these bands are typically an order of magnitude more intense than those of the surrounding excipients in the same frequency range, which provides the ability for THz-무료 바카라 게임 to directly measure “crystalline structure, crystalline disorder, and amorphous states,” with enhanced sensitivity. 

Between the study mentioned above [9] and a follow-up study published in 2015 [10], researchers at Bristol-Myers Squibb have provided a detailed analysis of the low-frequency 무료 바카라 게임 bands for polymorphs of some common APIs. In those two publications, they analyzed indomethacin, carbamazepine, caffeine, theophylline, and apixaban. Larkin et al. used a benchtop THz-무료 바카라 게임 sampling system, similar to the TR-BENCH currently available from Coherent shown in figure 4. The TR-BENCH has the same internal optical architecture as the TR-MICRO discussed in the previous section. As an example of this research, figure 5 shows the THz-Raman spectra of three different forms of carbamazepine. 

In recent years, THz-Raman spectroscopy has transitioned out of research laboratories and into pharmaceutical process monitoring applications, often referred to as process analytical technology (PAT) [21-24]. In process applications, fiber-coupled THz-Raman probes enable in-line, on-line, and at-line measurement, where the analyzer can be remote from the sample and does not need the sample to be captured and brought to the analyzer. Depending on the demands, the probe tip can be designed with a short working distance for direct immersion into a reaction chamber through an access port, or with a longer working distance to collect spectra through a viewing window. Figure 6 shows an example of the 무료 바카라 게임-PROBE with an immers무료 바카라 게임 probe tip attached.

Inoue et al used this approach to monitor the transition of carbamazepine form III to carbamazepine dihydrate, for various concentrations of ethanol and water [22]. The results shown in figure 7, were calculated using a multivariate curve resolution (MCR) algorithm with the dominant THz-무료 바카라 게임 bands of carbamazepine dihydrate (111 cm^-1) and carbamazepine III (39 cm^-1). Based on this data, the researchers were able to determine that the reaction produced the fastest 무료 바카라 게임nversion using a solution of 62.5% ethanol and 37.5% water. 

The Future of THz-무료 바카라 게임

While the pharmaceutical industry was the first to widely adopt THz-Raman, other sectors are using it to analyze crystallinity and polymorphism as well. A recent example is the use of THz-Raman to explore the relationship between mobility and strain [25], as well as charge transport and low-frequency vibrations [12] in organic semiconductors. It is also being used to analyze phonon modes in quantum dots [11], and layered semiconductor alloys [13]. Recently studies have been also published on polymer crystallization [10] and the formation of lamella during the cooling process [26], providing critical information about structural properties of products for the polymer industry. Perhaps the most exciting up and coming applications of THz-Raman are in biology and biomedical diagnostics. At the 2019 SPIE BiOS conference in San Francisco, Marble et al. presented the first talk on using THz-Raman for biological molecules [14], and a year later, THz-Raman was already being explored as a potential diagnostics tool for 무료 바카라 게임VID-19 [27].